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101 Science Drive

Box 90281,

Durham, NC 27708

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PUBLICATIONS

Cervical cancer diagnostics and treatment

  • Mueller J*, Asma B*, Lam C ,Krieger M, Asiedu M, Gallagher J, Hariprasad R, Malliga J, Mchome B, Oneko O, Taylor P, Venegas G, Wanyoro A, Muasher L, Schmitt J, Ramanujam N. International Image Concordance Study to Compare a Point-of-Care Tampon Colposcope With a Standard-of-Care Colposcope. Journal of Lower Genital Tract Disease, 2017. Epub ahead of print. PubMed.

  • Hu F, Morhard R, Murphy H, Zhu C, Ramanujam N. Dark field optical imaging reveals vascular changes in a spontaneous hamster cheek pouch model during carcinogenesis. Biomedical Optics Express, 2016, 7(9): 3247-61. PubMed.

  • Lam CT, Krieger MS, Gallagher JE, Asma B, Muasher LC, Schmitt JW, Ramanujam N. Design of a Novel Low Cost Point of Care Tampon (POCkeT) Colposcope for Use in Resource Limited Settings. PLoS ONE, 2015, 10(9): e0135869. PubMed.

  • Chang VT, Merisier D, Yu B, Walmer DK, and Ramanujam N. Towards a field-compatible optical Spectroscopic device for cervical cancer screening in resource-limited settings: effects of calibration and pressure. Optics Express, 2011, 19(19): 17908-24. PubMed.

  • Chang VT, Bean SM, Cartwright PS, Ramanujam N. Visible light optical spectroscopy is sensitive to neovascularization in the dysplastic cervix. Journal of Biomedical Optics, 2010, Journal of Biomed Optics, 15(5): 057006. PubMed.

  • Chang VT, Cartwright PS, Bean SM, Palmer GM, Bentley RC, Ramanujam N. Quantitative physiology of the precancerous cervix in vivo via optical spectroscopy.  Neoplasia, 2009, 11(4): 325-32. PubMed.

 

Breast cancer diagnostics and treatment

  • Nichols BS, Llopis A, Palmer GM, McCachren SS, Senlik O,  Miller D, Brooke MA, Jokerst NM, Geradts J, Greenup R, Ramanujam N. Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins. Journal of Biomed Optics, 2017, 22(2): 026007. PubMed.

  • Mueller J, Gallagher J, Chitalia R, Krieger M, Erkanli A, Willett R, Geradts J, Ramanujam N. Rapid staining and imaging of sub-nuclear features to differentiate between malignant and benign breast tissues at a point-of-care setting. Journal of Cancer Research and Clinical Oncology, 2016, 142(7): 1475-86. PubMed.

  • Kennedy S, Caldwell M, Bydlon T, Mulvey C, Mueller J, Wilke L, Barry W, Ramanujam N, Geradts J. Correlation of breast tissue histology and optical signatures to improve margin assessment techniques. Journal of Biomed Optics, 2016, 21.6: 066014. PubMed.

  • Fu HL, Mueller JL, Whitley MJ, Cardona DM, Kirsch DG, Brown JQ, Ramanujam N. Structured illumination microscopy and a quantitative image analysis for the detection of positive margins in a preclinical genetically engineered mouse model of sarcoma. PLoS ONE, 2016, 11(1): e0147006. PubMed.

  • Dobbs J*, Mueller J*, Krishnamurthy S, Shin D, Kuerer H, Yang W, Ramanujam N, Richards-Kortum R. Micro-anatomical quantitative optical imaging: towards automated assessment of breast tissues. Breast Cancer Research, 2015, 17:105. PubMed.

  • Nichols BS, Schindler CE, Brown JQ, Wilke LG, Mulvey CS, Krieger MS, Gallagher J, Geradts J, Greenup R, von Windheim K, Ramanujam N. A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins. PloS ONE,  2015, 10(6): e0127525. PubMed.

  • Nichols BS, Schindler CE, Brown JQ, Wilke LG, Mulvey CS, Krieger MS, Gallagher J, Geradts J, Greenup R, von Windheim K, Ramanujam N. A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins. PloS ONE,  2015, 10(6): e0127525. PubMed.

  • Brown JQ, Bydlon T, Kennedy SA, Caldwell ML, Gallagher JE, Junker M, Wilke LG, Barry WT, Geradts J, Ramanujam N. Optical Spectral Surveillance of Breast Tissue Landscapes for Detection of Residual Disease in Breast Tumor Margins. PLoS ONE, 2013, 8(7): e69906. PubMed.

  • Fu H, Mueller J, Javid M, Mito J, Kirsch D, Ramanujam N, Brown Q. Optimization of a Widefield Structured Illumination Microscope for Non-Destructive Assessment and Quantification of Nuclear Features in Tumor Margins of a Primary Mouse Model of Sarcoma. PLoS ONE, 2013, 8(7): e68868. PubMed.

  • Bydlon TM, Barry WT, Kennedy SA, Brown JQ, Gallagher JE, Ramanujam N. Advancing Optical Imaging for Breast Margin Assessment: An Analysis of Excisional Time, Cautery, and Patent Blue Dye on Underlying Sources of Contrast. PLoS ONE, 2012, 7(12): e51418. PubMed.

  • Kennedy SA, Geradts G, Bydlon T, Brown JQ, Gallagher J, Junker M, Barry W, Ramanujam N, Wilke L. Optical breast cancer margin assessment: an observational study of the effects of tissue heterogeneity on optical contrast.  Breast Cancer Research, 2010, 12(6):R91. PubMed.

  • Brown JQ, Bydlon TM, Richards LM, Yu B, Kennedy SA, Geradts J, Wilke LG, Junker M, Gallagher J, Barry W, Ramanujam N. Optical assessment of tumor resection margins in the breast. IEEE Journal of Selected Topics in Quantum Electronics, 2010, 12(3): 530-44. PubMed.

  • Bydlon TM, Kennedy SA, Richards LM, Brown JQ, Yu B, Junker MS, Gallagher J, Geradts J, Wilke LG, Ramanujam N. Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins. Optics Express, 2010, 19(8), 8058-76. PubMed.

  • Wilke LG, Brown JQ, Bydlon TM, Kennedy SA, Richards LM, Junker M, Gallagher J, Barry WT, Geradts J, Ramanujam N. Rapid non-invasive optical imaging of tissue composition in breast tumor margins. American Journal of Surgery, 2009, 198(4), 566-74. PubMed.

  • Brown JQ, Wilke LG, Geradts J, Kennedy SA, Palmer GM, Ramanujam N. Quantitative optical spectroscopy: A robust tool for direct measurement of breast cancer oxygenation and total hemoglobin content in vivo. Cancer Research, 2009, 69(7): 2919-26. PubMed.

  • Zhu C, Burnside ES, Sisney GA, Salkowski LR, Harter JM, Yu B, Ramanujam N.  Fluorescence Spectroscopy: An Adjunct Diagnostic Tool to Image Guided Core Needle Biopsy of the Breast. IEEE Transactions on Biomedical Engineering, 2009,  56(10): 2518-28. PubMed.

  • Zhu C, Breslin TM, Harter J, Ramanujam N. Model Based and Empirical Spectral Analysis for the Diagnosis of Breast Cancer. Optics Express, 2008, 16(19): 14961-78. PubMed.

  • Zhu C, Palmer G, Breslin T, Harter J, Ramanujam N. Diagnosis of Breast Cancer using Fluorescence and Diffuse Reflectance Spectroscopy: a Monte Carlo Model Based Approach. Journal of Biomedical Optics, 2008, 13(3): 034015. PubMed.

  • Zhu C, Palmer GM, Breslin T, Harter J, Ramanujam N. Diagnosis of Breast cancer using Diffuse Reflectance Spectroscopy: Comparison of a Monte Carlo vs. Partial Least Squares Analysis based Feature Extraction Technique. Lasers in Surgery and Medicine, 2006, 38(7): 714-24. PubMed.

  • Zhu C, Palmer GM, Breslin TM, Xu F, Ramanujam N. The use of a multi-separation fiber optic probe for the optical diagnosis of breast cancer. Journal of Biomedical Optics, 2005, 10(2): 24-32. PubMed.

  • Palmer GM, Zhu C, Breslin TM, Xu F, Gilchrist KW, Ramanujam N. Comparison of multi-excitation fluorescence and diffuse reflectance spectroscopy for the diagnosis of breast cancer. IEEE Transactions on Biomedical Engineering, 2003, 50(11): 1233-42. PubMed.

 

Hypoxia and metabolism (spectroscopy and microscopy)

  • Rajaram N, Reesor A, Mulvey C, Frees AE, Ramanujam N. Non-invasive, simultaneous quantification of vascular oxygenation and glucose uptake in tissue. PLoS ONE, 2015, 10(1): e0117132. PubMed.

  • Frees AE, Rajaram N, McCachren SS III, Fontanella AN, Dewhirst MW, Ramanujam N. Delivery Corrected Imaging of Fluorescently-Labeled Glucose Reveals Distinct Metabolic Phenotypes in Murine Breast Cancer. PLoS ONE, 2014, 9(12): e115529. PubMed.

  • Barrott JJ, Hughes PF, Osada T, Yang XY, Hartman ZC, Loiselle DR, Spector N, Neckers L, Rajaram N, Hu F, Ramanujam N, Vaidyanathan G, Affleck DJ, Zalutsky MR, Lyerly HK and Haystead T. Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells. Chemistry and Biology, 2013, 20(9): 118-97. PubMed.

  • Zhong J, Rajaram N, Brizel DM, Frees AE, Ramanujam N, Batinic-Haberle I, Dewhirst MW. Radiation induces aerobic glycolysis through reactive oxygen species. Radiotherapy and Oncology, 2013, 106(3): 390–6. PubMed.

  • Rajaram N, Frees AE, Fontanella AN, Zhong J, Hansen K, Dewhirst MW, Ramanujam N. Delivery rate affects uptake of a fluorescent glucose analog in murine metastatic breast cancer. PLoS ONE, 2013, 8(10): e76524. PubMed.

  • Liu C, Rajaram N, Vishwanath K, Jiang T, Palmer G, Ramanujam N. Experimental Validation of an Inverse Fluorescence Monte Carlo Model to Extract Concentrations of Metabolically Relevant Fluorophores from Turbid Phantoms and a Murine Tumor Model. SPIE: Journal of Biomedical Optics, 2012, 17(7): 077012. PubMed.

  • Millon SR, Ostrander JH, Brown JQ, Rajeha AM, Seewaldt VL, Ramanujam N. Uptake of 2-NBDG as a method to monitor therapy response in breast cancer cell lines. Breast Cancer Research and Treatment, 2011, 126(1): 55-62. PubMed.

  • Millon SR, Ostrander JH, Yazdanfar S, Brown JQ, Raheja AM, Ramanujam N. Preferential accumulation of 5-aminolevulinic acid-induced protoporphyrin IX in breast cancer: A comprehensive study on six breast cell lines with varying phenotypes. Journal of Biomedical Optics, 2010, 15(1): 018002. PubMed.

  • Ostrander JH, McMahon CM, Lem S, Millon SR, Seewaldt VL, Ramanujam N. The Optical Redox Ratio Differentiates Breast Cancer Cell Lines Based on Receptor Status. Cancer Research, 2010, 70(11): 4759-66. PubMed.

  • Vishwanath K, Yuan H, Barry WT, Dewhirst MD, Ramanujam N. Using Optical Spectroscopy to Longitudinally Monitor Physiological Changes within Solid Tumors. Neoplasia, 2009, 11(9): 889-900. PubMed.

  • Bird DK, Yan, L, Vrotsos KM, Eliceiri KW, Vaughan EM, Keely PJ, White JG, Ramanujam N. Metabolic Mapping of MCF10A Human Breast Cells via Multiphoton Fluorescence Lifetime Imaging Microscopy (FLIM) of the Coenzyme NADH. Cancer Research, 2005, 65(19), 8766-73. PubMed.

  • Palmer GM, Keely PJ, Breslin TM, Ramanujam N. Auto fluorescence spectroscopy of normal and malignant human breast cells. Photochemistry and Photobiology, 2003, 78(5): 462-69. PubMed.

 

 

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